Some packages depend on a specific version of python, which is why you’ll need a python version manager like pyenv. Some projects will conflict on specific versions of packages needed, so you’ll need a way to sandbox projects like pipenv. Here is my setup (indentation represents nesting):

python
pip
pyenv
	python(3.6.9)
	pip
		pipx
			pipenv

The top level python and pip are from the system, either installed by default or via the default package manager. pyenv lets us install other versions of python (and the corresponding pip). Since pip uninstall doesn’t cleanly uninstall packages¹, I installed pipx globally first, and then globally install the project manager pipenv under that. Initialize packages with pipenv install <package> in a project folder, and you’re good to go.